TARGETING ACTIVE RAS WITH MOLECULAR GLUE

Targeting active RAS with molecular glue

Activating Meat Grinder Parts mutations in RAS genes, notably KRASG12C, are pervasive in numerous cancers, presenting formidable challenges to therapy due to their elusive druggability.The landmark discovery of KRASG12C allosteric inhibitors marked a transformative milestone in cancer treatment, resulting in the approval of sotorasib and adagrasib.

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FEA-Swin: Foreground Enhancement Attention Swin Transformer Network for Accurate UAV-Based Dense Object Detection

UAV-based object detection has recently attracted a lot of attention due to its diverse applications.Most of the existing convolution neural network based object detection models can perform well in common object detection cases.However, due to the fact that objects in UAV images are spatially distributed in a very dense manner, these methods have

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Changing teaching techniques and adapting new technologies to improve student learning in an introductory meteorology and climate course

Responding to the call for reform in science education, changes were made in an introductory meteorology and climate Industrial Vacuum Accessory course offered at a large public university.These changes were a part of a larger project aimed at deepening and extending a program of science content courses that model effective teaching strategies for

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